Dear Dr. or Prof. XXXX (family name of the Editor or Editor-in-Chief who issued the decision
letter),
Thank you for your efficient work in processing our manuscript entitled “XXXX (title of the
article)” (Manuscript No: XXXX).
After we have carefully read the comments from the reviewers, we realize that the major merits of our work were not fully identified or recognized by the reviewers. Here we would emphasize that the most notable merits of our manuscript include：接着说你论文的advantage了。
I had opportunities to talk to Dr. XXX (of XXX University), and Dr. XXX (XXX University), and both of them read the manuscript and encourage me to write to you to ask if you could consider a revised version of the manuscript. (this should be included in the letter only if you have done so).Otherwise, this paragraph is not required.)
Point-by-point responses to the reviewers’ comments are enclosed after the letter for your
consideration.
In addition, this manuscript has been edited and proofread by Medjaden Bioscience Limited.
I will be most grateful if you could offer us a second opportunity (or an additional opportunity if the rejected manuscript is already a revised one).
Look forward to hearing from you soon,
With kind regards,
Yours sincerely，
Dear Dr.     ,
           Thanks for your email.
           I am sorry to learn that our manuscropt was rejected based on the comments "imporeditorial文章
tant but too specialized" from just one referee, as you may see the first referee ranked it as "highly important" with minor alterations. This reminded me of our another manuscript (sent to Angew. Chem. in October  2008) rejected under the quite similar conditions. And I would like to let you know that the work was already published as communication in JACS recently.
            Since there are only a very few processes (reported) which may be used to control the stereo- selective outcome with up to 5 chiral centers, I still think that our one pot strategy for generation of the bicyclic compounds with the control of 5 chiral carbons is highly valuable and the manuscript is very suitable to the readership of Angew. Chem. (a 4page-manuscript). As such, I would like to ask if you could send it to a third referee for a review and then reconsider your decision? Thank you very much for your help!
            I am looking forward to hearing from you.
Best regards,
*******
Dear xxx,
Thanks for your letter in response to our previous submission of our manuscript (ABAB-3437). After having carefully read your letter, I feel little bit confused as your decision. The two reviewers and you previously suggested that our manuscript (ABAB-3437) could be accepted for publication should we be prepared to incorporate minor revisions. We had revised our manuscript carefully and complemented some experiments raised by the reviewers. The rejected decision of the Editorial Board might be because that we did not answer some of the reviewers’ comments clearly. We carefully considered the reviewers’ comments again and have further modified the manuscript according to your letters. In addition, we have consulted a professional language editing services to check the English. 
We believe our manuscript (ABAB-3437) is potentially publishable for the following reasons. First, this work presents interesting results on  XXXXXXXXXX(省略……）
We understand that the misunderstanding might be caused by the unclear description in our manuscript, but we believe that the results are of merit and the paper is potentially publi
shable in the journal. Therefore, we would be most grateful if you could re-consider our work and give us a second opportunity. Thank you very much for your patience and understanding. Looking forward to hearing from you,
With best regards, 
Yours sincerely, 
xxx and xxx
通讯作者E-mail:xxx
通讯作者单位：xxx
Dear xxx,
Thanks for your letter in response to our previous submission of our manu (ABAB-3437). After having carefully read your letter, I feel little bit confused as your decision. The two reviewers and you previously suggested that our manu (ABAB-3437) could be accepted for
publication should we be prepared to incorporate minor revisions. We had revised our manu carefully and complemented some experiments raised by the reviewers. The rejected decision of the Editorial Board might be because that we did not answer some of the reviewers’ comments clearly. We carefully considered the reviewers’ comments again and have further modified the manu according to your letters. In addition, we have consulted a professional language editing services to check the English.
We believe our manu (ABAB-3437) is potentially publishable for the following reasons.
First, this work presents interesting results on XXXXXXXXXX(省略……）
We understand that the misunderstanding might be caused by the unclear deion in our manu, but we believe that the results are of merit and the paper is potentially publishable in the journal. Therefore, we would be most grateful if you could re-consider our work and give us a second opportunity. Thank you very much for your patience and understanding. Looking forward to hearing from you,
With best regards,
xxx and xxx